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The Epistemic Constitution: Architectural Separation and the Governance of Autonomous Machine Science

The transition from human-driven empirical inquiry to fully autonomous machine science represents the most profound epistemological threshold since the formalization of the scientific method. The emergence of Self-Driving Laboratories (SDLs) has transformed scientific discovery by integrating artificial intelligence with robotic automation, creating closed-loop experimental systems capable of autonomous hypothesis…

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The Epistemic Constitution: Architectural Separation and the Governance of Autonomous Machine Science
The Epistemic Constitution: Eviulon-Style Institutional Separation
The Scientific Claim Lifecycle
Machine-Readable Epistemic States
IARPA-Style Governance: Forecasting, Counterfactuals, and Adversarial Dynamics
Brier Score Calibration and the Bayesian Truth Serum
The Analysis of Competing Hypotheses (ACH)
Watershed I: The Synthetic Consensus Crisis

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